The sum of scientists working in laboratories worldwide today is greater than the sum of all the scientists who have existed throughout history – 90% of the researchers civilization has ever known are working right now. In 20th century, scientific development was a keystone of political and economic development. During that time, science moved from wanting to understand the world to wanting to change it Knowledge became a high percentage of the GNP of advanced nations. Science became techno-science, with a clear connection to business use. Private funding steps in, and these sources want profitable patents. But what will become of the great questions? We explore not only the technological but also the ethical, moral and economic limits of science.