Antibiotic Resistance is Becoming a Major Threat to Humanity

Pile of different color pills

As humans, we face a number of threats from the environment, but none may loom larger than the one posed by antibiotic resistance. Through our over prescription, poor regulation, agricultural abuse, and weak supply chains, a hyper-resistant bacteria is just around the corner. And unless we do something to change the tide, we may be looking at a pandemic of mass proportion.

Human presence on earth is a blip on the timeline compared to bacteria. And bacteria are pervasive; on our clothes, in our bodies, in dirt, and on the surface of pretty much everything – in fact, all of the bacteria on Earth, despite its microscopic size, would outweigh us 100 million times.

In the 3.5 billion years bacteria have lived on Earth, it has survived interminable challenges to its existence, which has only given it time to continuously adapt and outlast every other lifeform. Not to mention the fact that bacteria can reproduce 500,000 times faster than we can, with certain strains giving rise to a billion offspring within several hours.

Now that we’ve made it our mission to maintain sterile environments and avoid illness, we’ve been combating bacteria with chemicals and antibiotics every chance we get. Antimicrobials are used in everything from hand soap, to skin wipes, to yoga mats and kitchen towels, creating what can only be described as a Darwinian battleground, where only the strongest bacteria survive.

The Overuse of Antibiotics

Antibiotics were discovered during WWII, and prior to it’s discovery thousands of soldiers died from infection. When it became evident that antibiotics could easily cure bacterial disease, they became an instant panacea. But they weren’t used with a calculated strategy. Instead they were given as prophylactics, starting a dangerous trend of over-prescription.

Soon, the miracle drug known as penicillin was being prescribed by every doctor, whether there were only marginal chances an illness was caused by bacteria or not. And today that practice continues as doctors, who treat individuals, not society at large, would rather take the risk of over prescribing than having a patient get ill. It’s estimated that a third of all antibiotics are prescribed inappropriately, either when no bacterial infection is present, or the wrong antibiotic is recommended.

In 1945, the founder of penicillin, Alexander Fleming, warned the New York Times that doctors over prescribing the drug posed a serious threat to its efficacy. Though it wasn’t until the 70s that the FDA realized the potential fallout of antibiotic resistance.

By this point antibiotics were being used not just for humans, but almost universally for livestock as well. Farmers found they could raise animals in smaller, dirtier conditions if they staved off illness by incorporating antibiotics into their diet. And for some reason, still unknown to this day, a diet supplemented with antibiotics allows animals to grow slightly faster, producing more meat and subsequently more profit.

Today approximately 80 percent of all antibiotics in the U.S. are given to livestock, with the majority administered to healthy animals. This has created a vicious cycle in which farmers rely on the use of antibiotics to earn thin profit margins that would be eliminated if laws were enacted to restrict their use. Meanwhile, we’re eating the meat of these animals pumped with antibiotics, causing unknown health effects to us, while simultaneously promoting the growth of resistant bacterial strains.


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Antibiotic Resistance Causes: A Lack of Regulation

According to a 2016 World Economic Forum study, around 700,000 people die annually from antimicrobial resistance. That death toll will reach a total of 10 million by the year 2050.

So, why has the use of antibiotics been unregulated for so long? One answer is the rise in confinement agriculture, which put small farmers out of business and corporate agriculture at the forefront of meat production.

By the time the FDA realized the impending threat posed by antibiotic resistance and abuse, its widespread use was already ingrained in farming practices. The FDA proposed a ban for the use of antibiotics in animal feed by 1973, though it never came to fruition. Since then, the drug’s use has continually increased. The FDA merely provided recommendations to farmers to curtail the use of antibiotics, rather than getting legislation passed to mandate it.

So, who is preventing such legislation from being passed? Lobbyists from many industries, including big ag, pharmaceutical companies, and fast food chains relying on large quantities of cheap meat.

Today, there are nine billion animals raised for meat in the U.S. annually, with 90 percent of those animals raised in concentrated animal feeding operations, or CAFOs. These CAFOs, that contribute to a number of public health problems, are often owned by large corporations that pack as many animals into their enclosures as possible, barely maintaining their health with antibiotics.

Since the 1980s, mega-farms have overtaken markets, putting 85 percent of small farmers out of business. They began producing more meat at a faster rate, driving the market price of an animal down, sometimes by more than half. Now that this has become common practice, farmers fear they can’t afford to take a step back and revert to pre-antibiotic farming practices.

Misuse, Overuse and Refuse

The U.S. healthcare system is flawed, causing many to resort to desperate tactics when in need of medicine. While antibiotics aren’t necessarily expensive compared to other drugs, a trip to the doctor can cost the uninsured hundreds of dollars. To avoid this, people take matters into their own hands to save a buck, contributing to a greater problem and also putting them in a dangerous position.

On the extreme end, people have begun using over-the-counter animal antibiotics from pet stores to treat bacterial issues ranging from infections from wisdom teeth extraction to bronchitis. On the less extreme end, people often save unfinished antibiotics for future illness.

There’s debate as to whether patients should finish a prescription or stop once they start feeling better, but typically the dosage and type of antibiotic are tailored to a specific infection. There are also different strengths of antibiotics that have slowly become ineffective as bacteria have grown resistant. And not finishing a prescription can leave bacteria in your body that can grow stronger.

But even if we take proper dosages and get prescriptions from a doctor, there’s still the problem of waste and antibiotics seeping into the environment from a multitude of sources. Pharmaceutical pollution creates a fecund environment for antimicrobial resistance, and recent events have only perpetuated this.

A few years ago, there was an explosion at a Chinese factory that produced antibiotic precursors. This undoubtedly lead to more pollution, but it also lead to a major gap in the global antibiotic supply chain that relied on a tenuous supply of the drugs. This shortage, particularly of one antibiotic that prevents the spread of syphilis from mother to child, can exacerbate antimicrobial resistance while allowing the spread of disease.

Now that bacteria are evolving to quickly become drug resistant, pharmaceutical companies and their investors have no incentive to finance research into new antibiotics that could become useless within five years. When it costs a billion dollars to bring a new drug to market, there’s no chance our capitalist model will produce them at a loss.

What can we do before it’s too late? Awareness and pressure on the government to pass legislation limiting antibiotic use is key. While it seems hopeful at best, raising awareness can lead to a greater number of people observing best practices that limit resistance.

Pressuring governments, organizations, and private companies to enact policies can lead to change too. Encouraging doctors to prescribe fewer antibiotics, while consuming fewer ourselves, especially those from alternative sources, can slow the process of resistance.

Currently, one company, CARB-X, is working to speed up the development of new drugs that most big pharmaceutical companies won’t consider. The company’s funding is a mix of private and public partners working to find solutions to antimicrobial resistance.

In the E.U., the use of antibiotics in agriculture has been banned, and though there has been a slight decrease in animal growth and a slight increase in animal mortality, overall meat production is higher than when antibiotics were used.

If they can do it, so can the U.S. And though it may seem like something beyond individual control, it can be possible to collectively enact change by starting at the individual level.

Curing the Next Great Plague

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Mites, Monsanto Cause Colony Collapse Disorder; Is Fungi A Solution?

Something has killed honey bees in droves for the past 20 years leading to what’s known as colony collapse disorder. For a while, the culprit remained ambiguous, but now scientists are discovering that a number of anthropogenic factors, including Monsanto’s herbicide glyphosate, pesticides, and parasites may be to blame. Though these may seem like disparate problems requiring complicated solutions, there is one man who believes he has an answer that could save the bees—that man is Paul Stamets, and his answer is fungi.

Over the past several years, Stamets has become something of a rockstar in the field of mycology—the study of fungi—for his radical and pioneering work discovering the endless applications and influences mushrooms have on our world.

Since he began researching fungi in the 1970s, Stamets has received 12 patents, written six books, and been recognized by a multitude of esteemed institutions. There’s even a character on Star Trek: Discovery named after him—Lt. Cmdr. Paul Stamets.

Part of Stamets’ appeal stems from his Deadhead-turned-scientist persona that views fungi from a spiritual perspective, not just a materialist lens. Stamets admits his early use of Psilocybe cubensis, also known as “magic” mushrooms, became the catalyst for his fascination, leading to a lifelong journey studying the myriad mycelia that populate the planet.

Stamets’ discoveries have changed lives and now he hopes to parlay his mushroom knowledge into a comprehensive plan to save the bees, and in the process, maybe save humanity as well.

Colony Collapse Disorder

Colony collapse disorder is the phenomenon in which there is a mass exodus of worker bees from the hive, typically dying or fleeing from infection. These bees leave their queen behind with a few nurse bees to care for her, though their chances for survival drop significantly, especially as winter draws near. Scientists have identified several factors related to colony collapse, most of which stem from pathogens and chemicals that degrade bees’ immune systems.

And while we all know bees produce honey and wax, many don’t realize just how crucial they are to our survival as a species.

Bees are pollinators, and while this may seem obvious, many are unaware of just how essential bee pollination is to agriculture. When a bee collects nectar from a plant it picks up pollen and transmits it to other plants, allowing them to bear fruit. And a single bee can pollinate up to 1000 flowers a day.

This process is necessary for our agricultural industry, as about 35 percent of our food is directly dependent on bee pollination, while the other 65 percent is indirectly dependent. If bee pollination suddenly ceased, it’s estimated around $16 billion worth of crops would be affected in the United States alone.

And over the past few decades, beekeepers and entomologists have noticed massive drop-offs in bee populations globally. In a matter of a single year, states like Oklahoma lost as much as 85 percent of beehives due to colony collapse. According to the U.S. Dept. of Agriculture, a third of all bee colonies have died each year since 2006. So, what exactly is causing this apiological pandemic?

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