DIY Medicine; One Man’s Crusade Against Big Pharma

EpiPencil

The public outrage that ensued over the hyperinflation of a cancer drug, villainized Martin Shkreli and made him the poster child of everything that is wrong with Big Pharma. And while the “pharma bro” is now in jail for his unashamed price gouging, amongst other things, the overarching problem of the exorbitant cost of these drugs hasn’t really been addressed. Since the issue is not going to be solved through government any time soon, it has led the terminally-ill and those with an anarchist sentiment to start creating DIY medicine. Could this really be a viable solution?

DIY Medications

Open-source technology is an amazing thing, and it has allowed anyone with a good idea the ability to create solutions to our daily problems without having to jump through the hurdles of patents and legal technicalities. But now the concept of open-source is being taken a step further, by creating a platform for DIY drugs to combat inflation on a product that has life or death consequences.

Michael Laufer, a P.hD. mathematics professor-turned-pharmahacker, has started to combat the ever-increasing cost of pharmaceuticals by making them himself and uploading instructions for others to do so online. Laufer’s first success was the EpiPencil, a homemade EpiPen that can be made for as little as $30. EpiPens, which now exceed $600 for a two-pack, have sky-rocketed, nearly tripling over the past few years. Meanwhile, the price of one dose of epinephrine will run you about a dollar.

Providing not only instructions on how to acquire the necessary ingredients and synthesize the drug, Laufer also includes a label with the name and logo of his bio-hacktivist website, Four Thieves Vinegar.

Laufer has also uploaded the instructions for an “apothecary microlab” and an outline for synthesizing Daraprim, the cancer drug that made Shkreli infamous. In the near future, he also plans to upload directions for followers to make an HIV preventative, a Hepatitis-C treatment, and a drug combination used for abortions. Though the latter isn’t necessarily a drug needed for life-or-death illness, that is Laufer’s defense when he is criticized for promoting potentially dangerous DIY treatments; there are many desperate people who, faced with a life-or-death decision and unable to afford their prescriptions, are willing to try anything, including manufacturing medicine themselves.

 

DIY Medications

 

Though Laufer has come under heavy criticism for advocating this kind of behavior, he has yet to face any serious consequences or lawsuits. The FDA has warned against the use of homebrew medications in response to his popularity, but it hasn’t banned it. Though the FDA does bring up some good points as to why the idea is pretty sketchy: home synthesis is easily contaminated, you could synthesize a sub-potent or super-potent drug, and you could be creating or buying counterfeit substances.

The impetus for starting this whole project came when Laufer was working in El Salvador on a human rights mission, noticing that a local clinic was running out of basic medication, like birth control. In an area where gang violence and illegal meth labs were prevalent, he thought that there should be a way for locals to synthesize legal drugs on their own, saying that it wasn’t that much different from cooking methamphetamine. This led him to start 4 Thieves Vinegar and change his career path to one that now involves medicine.

 

DIY Prescriptions May Someday Be Common

Aside from the arbitrarily high inflation that pharmaceutical companies impose on drugs, benefitting only their shareholders, transportation and distribution are also lofty expenses. Cold chain distribution, the logistical transport of drugs that need to be kept frozen or cold, is an incredibly lucrative business and one that adds to the cost of already expensive medicine. It is an industry that is expected to be valued at almost $17 billion in the next two years.

So, wouldn’t it make sense to skip that step and cut down on the price of these heat sensitive medicines if possible? Well, that’s exactly what Wyss Industries is proposing with its portable biomolecule manufacturing. After having some success with this technology, originally created for getting vaccines to remote villages lacking access to electricity and infrastructure, the company has considered it as a solution to combat the rising price of medicine in the first world.

 

freeze-dried-medicine

 

Basically, the technology allows the essential components of a medication to be freeze-dried into tiny pellets that can be activated simply by adding water. These pellets can store for up to a year without the refrigeration normally needed. It also reduces the risk of messing up some critical step in synthesizing DIY drugs, when all you need is to add a carefully measured amount of water.

 

Homebrew Medications as a Cancer Moonshot

In Norway, a man suffering from a rare form of cancer had very few options left, with none of his medications working and a lack of resources to access treatment from specialists. He and his wife heard about a very particular experimental treatment that succeeded in China on someone suffering from the exact same type of cancer he had. The treatment was simple and cheap, but it was tailored specifically to this patient and wasn’t guaranteed to work on just anybody.

Unable to get a specialist to make the drug for him, his wife ordered the ingredients and had a lab synthesize a peptide component in the drug. When she had all $1000 worth of the ingredients, she paid for the use of a lab and made the drug herself. Though it wasn’t necessarily easy, she said it wasn’t rocket science and relatively cheap, compared to what it would cost otherwise. She has been giving him the drug in addition to his normal treatment, and his symptoms seem to have leveled off.

Though they can’t tell for sure whether the drug is having a significant impact yet, there are many risks with these treatments. But the argument for their use is the alternative of death. When nothing is working and death is imminent, most people are willing to try anything.

Do you think DIY medications are a good idea or does the danger outweigh the potential benefit?



Mites, Monsanto Cause Colony Collapse Disorder; Is Fungi A Solution?

Something has killed honey bees in droves for the past 20 years leading to what’s known as colony collapse disorder. For a while, the culprit remained ambiguous, but now scientists are discovering that a number of anthropogenic factors, including Monsanto’s herbicide glyphosate, pesticides, and parasites may be to blame. Though these may seem like disparate problems requiring complicated solutions, there is one man who believes he has an answer that could save the bees—that man is Paul Stamets, and his answer is fungi.

Over the past several years, Stamets has become something of a rockstar in the field of mycology—the study of fungi—for his radical and pioneering work discovering the endless applications and influences mushrooms have on our world.

Since he began researching fungi in the 1970s, Stamets has received 12 patents, written six books, and been recognized by a multitude of esteemed institutions. There’s even a character on Star Trek: Discovery named after him—Lt. Cmdr. Paul Stamets.

Part of Stamets’ appeal stems from his Deadhead-turned-scientist persona that views fungi from a spiritual perspective, not just a materialist lens. Stamets admits his early use of Psilocybe cubensis, also known as “magic” mushrooms, became the catalyst for his fascination, leading to a lifelong journey studying the myriad mycelia that populate the planet.

Stamets’ discoveries have changed lives and now he hopes to parlay his mushroom knowledge into a comprehensive plan to save the bees, and in the process, maybe save humanity as well.

Colony Collapse Disorder

Colony collapse disorder is the phenomenon in which there is a mass exodus of worker bees from the hive, typically dying or fleeing from infection. These bees leave their queen behind with a few nurse bees to care for her, though their chances for survival drop significantly, especially as winter draws near. Scientists have identified several factors related to colony collapse, most of which stem from pathogens and chemicals that degrade bees’ immune systems.

And while we all know bees produce honey and wax, many don’t realize just how crucial they are to our survival as a species.

Bees are pollinators, and while this may seem obvious, many are unaware of just how essential bee pollination is to agriculture. When a bee collects nectar from a plant it picks up pollen and transmits it to other plants, allowing them to bear fruit. And a single bee can pollinate up to 1000 flowers a day.

This process is necessary for our agricultural industry, as about 35 percent of our food is directly dependent on bee pollination, while the other 65 percent is indirectly dependent. If bee pollination suddenly ceased, it’s estimated around $16 billion worth of crops would be affected in the United States alone.

And over the past few decades, beekeepers and entomologists have noticed massive drop-offs in bee populations globally. In a matter of a single year, states like Oklahoma lost as much as 85 percent of beehives due to colony collapse. According to the U.S. Dept. of Agriculture, a third of all bee colonies have died each year since 2006. So, what exactly is causing this apiological pandemic?

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