Study Finds Lack of These Two Gut Bacteria May Lead to Depression

Shot of unhealthy young woman with stomachache leaning on the bed at home.

As studies of our microbiota become more focused, scientists have realized that our guts are inextricably linked to the brain and its functions. We now know our gut definitively factors into decision making, though we’ve probably known this informally for hundreds of years, hence the phrase “go with your gut instinct.” And now a new study believes it has pinpointed two specific species of bacteria that, when missing from our microbiome, may lead to depression.

According to the study recently published in the journal Nature Microbiology, out of a group of 2,000 participants, researchers found that those reporting symptoms of depression were lacking two particular strains of bacteria in their gut – Coprococcus and Dialister.

Coprococcus in particular was found to be a pathway for dopamine, the neurotransmitter believed to play a role in our brain’s reward system – one that’s known to dysregulate in people experiencing depression.

Though their results are only early indicators that will require significantly more research to be applicable for any future treatment, these two bacterial strains could lead to a future in which doctors might prescribe probiotics to treat mental disorders, or what some are referring to as “psychobiotics.”

The ability for our gut bacteria to send neurotransmitters between the brain and our gut’s brain, the enteric nervous system, is not found in bacteria outside of our guts and is believed to have evolved as we did.

This enteric nervous system, often called our second brain, contains somewhere in the range of 200 to 500 million neuronal pathways of its own – about the same as a dog’s brain – and communicates with the cerebellum through a two-way highway called the vagus nerve.

Our gut microbiome has something in the range of 500 to 1000 different species of bacteria, with scientists continuously discovering new ones. And in this most recent study, of the more than 500 strains tested, 90 percent of those strains were capable of producing neurotransmitters.

These bugs in our gut form somewhere in the range of three to five pounds of biomass and have essentially evolved to control our behavior. Along with the fungi, viruses, archaea, and other microbial cells, our guts are believed to contain somewhere in the range of 37 trillion bacterial cells. And unless we proactively maintain them, losing diversity in our microbiota can have severely negative side-effects. Now we’re closer to knowing that depression may be one of them.



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The Wonderful Benefits of Japanese Knotweed

While the anti-cancer and brain-healing resveratrol is found in grapes, blueberries, peanuts, cashews. cocoa powder, and wine, this powerful antioxidant is wildly abundant (more than grapes) in Japanese Knotweed. Resveratrol is unusually powerful and a natural phenol, found in a unique group of micronutrients with antioxidant properties.

This puts Knotweed in an elite class of supremely healing and helpful herbs. In recent years, it’s become a vital medicinal, culinary, and ceremonial herb throughout Korea, China, and Japan, and within several spiritual communities in the United States and Europe. 

This beautiful green and white plant is also extremely fertile. When planted among other vegetation, Japanese Knotweed becomes invasive and ravages the land, often consuming neighboring crops. Because it’s also difficult to eradicate, some folks consider this herb an enemy. Japanese Knotweed is also known as Itadori tea. The Japanese word itadori can be translated as “remove pain.” It’s used in traditional Chinese and Japanese medicine. Meanwhile, when foraged in the wild, its young stems are edible, albeit sour, with a flavor reminiscent of rhubarb. The plant can be found in 39 of the 50 United States.

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