Whether you call it ascension, enlightenment or transcendence it all means the same thing: being inexplicably drawn to experience a state of being beyond the limits of physical perception.
In the modern era, it undoubtedly means the convergence of cutting edge science with the wisdom of the ages. This is why it is important to realize that we are not limited to the body. We are spiritual and divine beings, just now awakening to our potential.
To embrace that awakening, one must learn to reach out to this other world and gain perception of it through tools like divination and manifestation. Divination allows you to gain spiritual information beyond physical means, manifestation allows you to enact change in the physical through spiritual means.
Consciousness is important. Being aware of your state and working to expand the limits of consciousness beyond the limits of the physical world.
A long-tested way of expanding consciousness is through regular spiritual practice. This is found with Buddhism, Hinduism, and even esoteric Christianity. The religious doctrine is less important than the discipline of working with the mind and your ability to perceive.
The pursuit of ascension tends to initially be the pursuit of knowledge and becomes experiential. Sacred sciences through the ages have tinkered with the connection of consciousness with the material world. Thus we begin to form a bridge between Alchemy and Quantum Theory.