Scientists Find Breakthrough Use of Light to Kill Cancer Cells
In a world-first, scientists have developed a breakthrough treatment that uses light to kill cancer cells.
We often think of light as a life-giving source, but in the case of photoimmunotherapy — the use of light to help a person’s own immune system fight cancer — light can both be a source of life, for the patient, and death, to cancer cells.
A multidisciplinary team of European scientists joined forces to design the new treatment, which works by combining a special fluorescent dye with a cancer-targeting compound.
Shining light on the compound forces cancer cells to glow in the dark, helping surgeons to remove more of the tumors compared with existing techniques.
Then, the surgeon would shine near-infrared light on the site, switching the compound into tumor-killing mode and killing off any remaining cells.
The trial of this therapy was done on mice with a particularly aggressive form of brain cancer called glioblastoma.
Findings showed that the mice had clear signs of tumor death in as little as one hour after exposure to the light. The treatment also triggered an immune response that could mount a new attack on cancer should it come back.
Study leader Dr. Gabriella Kramer-Marek told The Guardian, “Brain cancers like glioblastoma can be hard to treat, and sadly, there are too few treatment options for patients. Surgery is challenging due to the location of the tumors, and so new ways to see tumor cells to be removed during surgery and to treat residual cancer cells that remain afterward could be of great benefit.”
Scientists are quite hopeful that the results will be duplicated when they study the treatment of humans. In the meantime, this trial has shined a light at the end of a long, dark tunnel.
You Can Rewire Your Brain to Eliminate Chronic Back Pain
A groundbreaking new study shows the remarkable efficacy of a brain-based treatment for chronic back pain. It provides new hope for a debilitating problem.
One in five Americans suffers from chronic pain, most often without receiving many benefits from invasive and costly treatments.
The most common type of chronic pain is chronic back pain- in 85% of cases of which no physical cause can be identified.
Dr. Yoni Ashar is a clinical psychologist and neuroscientist who studies psychological treatments for chronic pain. He recently led a study at the University of Colorado Boulder to determine whether a psychological treatment can eliminate chronic back pain — something no other therapy has ever before been scientifically proven to do.
“Our society predominantly thinks about chronic pain through a biomechanical, medical perspective. The most common treatments are physical; they’re injections or physical therapy, something targeting the body. What we’re learning more and more is that in many cases of chronic pain the problem lies in the mind or the brain. And we now have decades of research, both in neuroscience medicine and psychology, showing that there are a lot of changes that happen in the brain during chronic pain. In many cases, these can cause the pain to persist after an injury has healed.”
An important distinction that should be made when discussing chronic pain is that between the two types — primary and secondary.
“With secondary chronic pain, the pain is secondary to some medical problem or disease. With primary pain the pain is the primary problem, it is not secondary to anything else. What really is driving it are neuroplastic changes in the brain, and fear and avoidance. Fear is at the heart of chronic pain, so pain is a danger signal. The fundamental function of pain is to guide a person or animal away from things that are dangerous and when we perceive things to be dangerous that can amplify or even create this pain in our brains.”
