Scientists Find Breakthrough Use of Light to Kill Cancer Cells
In a world-first, scientists have developed a breakthrough treatment that uses light to kill cancer cells.
We often think of light as a life-giving source, but in the case of photoimmunotherapy — the use of light to help a person’s own immune system fight cancer — light can both be a source of life, for the patient, and death, to cancer cells.
A multidisciplinary team of European scientists joined forces to design the new treatment, which works by combining a special fluorescent dye with a cancer-targeting compound.
Shining light on the compound forces cancer cells to glow in the dark, helping surgeons to remove more of the tumors compared with existing techniques.
Then, the surgeon would shine near-infrared light on the site, switching the compound into tumor-killing mode and killing off any remaining cells.
The trial of this therapy was done on mice with a particularly aggressive form of brain cancer called glioblastoma.
Findings showed that the mice had clear signs of tumor death in as little as one hour after exposure to the light. The treatment also triggered an immune response that could mount a new attack on cancer should it come back.
Study leader Dr. Gabriella Kramer-Marek told The Guardian, “Brain cancers like glioblastoma can be hard to treat, and sadly, there are too few treatment options for patients. Surgery is challenging due to the location of the tumors, and so new ways to see tumor cells to be removed during surgery and to treat residual cancer cells that remain afterward could be of great benefit.”
Scientists are quite hopeful that the results will be duplicated when they study the treatment of humans. In the meantime, this trial has shined a light at the end of a long, dark tunnel.
Why Do We Sleep? For More Reasons Than You May Think
Most of us spend about a third of our lives asleep, despite not really having an answer to the question, ‘why do we sleep?’ Now neuroscientists are realizing that sleep is more important than previously thought. They’re also realizing that the worn-out platitude, “you can sleep when you die,” is terrible advice, as that day will undoubtedly come sooner if you short yourself on a good night’s sleep.
You need to be getting seven to eight hours of sleep every night — there’s really no other way around it. And if you think you can healthily get by on less than that, there’s an almost 100 percent chance you’re fooling yourself.
Why is Sleep Important?
While the exact mechanisms of sleep are still being studied, neuroscientists including Matthew Walker have made interesting learnings about what happens when we deprive ourselves of sleep and the impacts sleep (or lack thereof) has on society as a whole.
When we’re awake, Walker says that essentially, we’re causing low-level brain damage. By this, he is referring to the build-up of the sticky, toxic junk in our brain known as beta-amyloid. This accumulation of beta-amyloid has been found to correspond with the onset of Alzheimer’s, among many other adverse health effects correlated with a lack of sleep.
Sleep is beneficial as more than just a healing function; it also replenishes spent resources and regulates hormone levels that dictate our appetite, cognitive function, and motor skills. The two hormones that dictate whether we are hungry or full, ghrelin and leptin, have been observed to flare up and down, respectively, when we’re sleep deprived. This inevitably leads to an increase in hunger, but even worse, it leads our bodies to crave unhealthy and fattening foods — those heavy on carbs and light on greens. In fact, people who run on four to five hours of sleep per night tend to eat 200-300 more calories per day.
For men, sleep is an important regulator of hormones, most notably testosterone. Sleep-deprived males can have the same virility and strength as a man 10 years their senior. For women, a lack of sleep can lead to a significantly increased risk of breast cancer and drops in immune hormones.
According to Walker, just introducing a single night of just four hours of sleep among a normal eight-hour sleep schedule, can bring about a 70 percent drop in natural cancer-killing cells, the immune assassins that target malignant carcinogens. Every day our bodies produce these cells and others to fend off disease and maintain our health, and while a cat nap might make you feel refreshed, it won’t make up for the loss of these cells.
