Strongest Psychedelic Known to Man Now Being Used in Clinical Trials
The world’s first regulated clinical trial of DMT clears the way for Earth’s most powerful psychoactive drug to join the psychedelic therapy revolution.
DMT, or N, N-Dimethyltryptamine, is a highly potent hallucinogen that naturally occurs in many plant species, including in one of the plant ingredients of ayahuasca. It can also be synthetically produced in a laboratory.
DMT is known for inducing intense metaphysical trips, which are reportedly similar to near-death experiences. Having been used underground in the west for decades, it is now attracting the interest of pharmaceutical companies and scientists looking to investigate its potential mental health benefits.
Jay Waxenberg is the director of the DMTx program at the Center for Medicinal Mindfulness. Based in Boulder, CO, it was one of the first centers to offer legal psychedelic therapy in the U.S.
“DMT is actually the most powerful psychedelic on Earth that we’re aware of, and what makes it special and different from other psychedelics is that it’s endogenous, which means it’s produced within our own bodies. It’s also produced in nearly every ecosystem on Earth — it’s everywhere, it’s all around us – which is also kind of leading to what is really unique about it, the extent of a DMT experience, it’s at most 20 minutes,” Waxenberg said.
While there is a wide range of phenomena experienced during a DMT trip, there are some fascinating common hallmarks.
“This alternate reality experience, or this experience that people will call ‘realer than real.’ It’s a reality similar to our own, but completely different,” Waxenberg said. “Some of the elements within that would be the entity encounters, which is very common for people; intense geometric, hyperbolic shapes; and out-of-body, traveling to the center of the universe; ego-dissolution, ego death; these are really common experiences under it.”
While advocates have been reporting profound healing benefits for decades, there have not been any clinical studies on DMT due to its status as a Schedule 1 controlled substance, until now.
Canadian pharmaceutical company small pharma recently completed the first clinical trial of DMT-assisted therapy. The trial was Phase 1, meaning it established the safety and feasibility of studying the psychedelic in this way.
Small pharma is now moving into Phase 2 trials involving patients with Major Depressive Disorder. Practitioners like Waxenberg have high hopes that the studies will bear out DMT’s great potential for addressing psychological issues.
“If somebody has an ego death, or somebody leaves their body, there’s this feeling of expansiveness that comes with that; a feeling of not feeling trapped in your life. So, if you’re in depression, or anxiety, or thought-loop patterns, or anything like this, often that’s the benefit — to break yourself out of those cycles, to break yourself out of those loops or thought patterns. In the dying process, people who are getting terminal diagnoses, that’s where the most benefit can come because it’s an instantaneous removal of the ego and out of your body to go into that space; experiences that take them right into what they believe the afterlife process will be or what they believe the death process will be — and really watching that be nourishing and supportive of, ‘Ok, this is maybe something I can actually go toward,’” Waxenberg said.
“Also, it’s going to have really big benefits toward treatment-resistant depression. Like ketamine, it’s this out-of-body experience that alone can help reset the nervous system, reset what your baseline is of happiness or wellness, it can get totally reset just like that.”
Many in the psychedelic therapy world will be watching closely for the results of the coming DMT-assisted therapy trials.
“My hope is to just keep opening the door wider and wider, as we bring more and more people into the space, more and more people into the conversation to see what these substances can do. And really within this meta-crisis, we find ourselves in culturally, I think DMT is an answer to a lot of those questions; how can we really see a different angle to the problems that we face?”
Brain Scans of Shamans Show Ability to Alter Consciousness Naturally
A new study is the first to investigate what occurs in an alternate state of consciousness by looking inside the brain of a shaman.
Shamanism is considered to be the most ancient form of healing and spiritual practice. While science has been studying the healing benefits of the psychoactive plants used by shamans to enter into an altered state of consciousness, there have been very few studies to look at the neurological nature of the state itself. A groundbreaking new study investigated the shamanic state of consciousness accessed without the use of psychedelics.
Carlos Tanner is a longtime student of traditional shamanism and the director of the Ayahuasca Foundation. an educational and ceremonial center in Peru. “Shamanism refers to an alternate dimension, a dimension where spirits reside, where communication is possible, where greater insights can be acquired and brought back to the waking-day life,” Tanner said. “So a shaman would be someone who can enter into a different dimension and then pull that back.”
The process by which shamans access this state is rooted in the rich tradition of what Tanner calls, a ‘science of consciousness enhancement.’
“Oftentimes, there is the term ‘ceremony’ to describe the intentional entrance into this shamanic state. So there would be a preparation where there might be rituals to essentially prepare, certain clothing might be worn, and the use of certain tools, oftentimes a musical instrument, might be used,” Tanner said.
“All of those are a beautiful science of consciousness enhancement that, I think, has been developed through the continual use of a psychotropic substance, although to a point where, in many cases, the psychotropic substance is no longer needed to enter that state because the consciousness enhancement that was provided by the psychotropic substance can be accomplished without it.”
Richard Harris Ph.D. is a researcher at the University of Michigan who conducted the recent study on the shamanic state of consciousness. Dr. Harris and his team were interested in investigating this state in its purest form, unaffected neurologically by the use of any exogenous substances. To facilitate the entrance into the altered state without the use of psychedelics, the practitioners all listened to a recording of shamanic drumming.
“So, we did a study with 24 shamanic practitioners and 24 normal, control individuals and we collected EEG data (electroencephalogram data), you know brain activity data, while each participant had their eyes closed while they were listening to classical music which was the control condition, and then while they were listening to shamanic drumming music which was the more experimental condition,” Dr. Harris said. “So, what we’re doing with the shamanic drumming, we’re using the person’s own physiology to engender the state.”
