New Studies Find Psychedelics Highly Effective for Alcoholism
New studies show unprecedented success in the treatment of alcoholism with psychedelic therapy.
The psychedelic revolution in mental health has produced overwhelming scientific evidence demonstrating the great efficacy of psychedelics in the treatment of various mental health disorders. Now, several new studies involving the drugs ketamine and MDMA are showing significant promise in the treatment of alcoholism.
Dr. Ben Sessa is a psychiatrist and chief medical officer at Awakn Life Sciences, an English biotech company that is at the forefront of the research, development, and delivery of psychedelic medicines.
The company is especially focused on the treatment of Alcohol Use Disorder or AUD, given how prevalent and challenging it is to treat.
“Alcoholism is a huge public health problem. It’s also a psychiatric condition that’s very poorly treated with very poor outcomes with traditional methods,” Sessa said. “Relapse to drinking after getting dry is around 80 to 90 percent at 12 months. That’s an embarrassingly poor statistic. Psychedelics offer a completely new approach; they offer the patient to explore the root causes of addiction, which so often is trauma. Psychedelic-assisted psychotherapy is an intensive upfront piece of work that gets the patient better, so they don’t have to keep coming back. It is a completely different paradigm shift to the way we currently manage patients in maintenance therapies.”
A recent study conducted by researchers at the University of Exeter and Awakn Life Sciences is the world’s first to examine the use of ketamine to treat AUD in a randomized controlled trial.
“Ketamine is a very well-established human medicine. It is indeed the only psychedelic that’s licensed as a medicine, as an anesthetic medicine, and has been used since the 60s as such. It’s an incredibly safe medicine. When it’s used at a much lower dose, it produces an altered state of consciousness. What we do in psychedelic-assisted psychotherapy with ketamine, is we use this altered state of consciousness to affect a more effective and deeper form of psychotherapy. So, we’re using ketamine as an adjunct to psychotherapy to treat addictions,” he said.
Participants in the study had all just completed a medically supervised alcohol detox program. Those in the experimental group received treatment with both ketamine and a form of psychotherapy called KARE over the course of four weeks.
“The group that received ketamine and specific KARE psychotherapy led to an 86 percent abstinence rate at six months — absolutely blows out of the water the current best treatments for alcoholism,” Sessa said.
Just what accounts for these astounding results?
“So we know a fair bit about the mode of action of ketamine, you literally grow new brain tissue after taking ketamine,” Sessa said. “Now, this is hugely helpful because when you combine that — when you think of it as a super-ripe brain bristling with neuronal activity — with psychotherapy in which you are asking the patient to address the psychological issues that are usually around stuck, rigid narratives they hold, then you can grow this new neural tissue in the direction you want to have changes to their psychology. This is a huge breakthrough for addictions, which is so much about rigidity and stuck-ness.”
The implications of this groundbreaking study are truly profound.
“Once we get the drug actually licensed and approved for, specifically, alcohol-use disorder, it hugely broadens the accessibility and far more clinicians would be willing to be using this in a much broader way. So, it will really radically change the field of treatment of alcoholism all over the world,” he said.
In addition to their work with ketamine, Awakn has also recently completed a study with another psychoactive drug MDMA which has yielded equally significant findings.
Watch Pt. 2 of our interview with Dr. Ben Sessa:
Strongest Psychedelic Known to Man Now Being Used in Clinical Trials
The world’s first regulated clinical trial of DMT clears the way for Earth’s most powerful psychoactive drug to join the psychedelic therapy revolution.
DMT, or N, N-Dimethyltryptamine, is a highly potent hallucinogen that naturally occurs in many plant species, including in one of the plant ingredients of ayahuasca. It can also be synthetically produced in a laboratory.
DMT is known for inducing intense metaphysical trips, which are reportedly similar to near-death experiences. Having been used underground in the west for decades, it is now attracting the interest of pharmaceutical companies and scientists looking to investigate its potential mental health benefits.
Jay Waxenberg is the director of the DMTx program at the Center for Medicinal Mindfulness. Based in Boulder, CO, it was one of the first centers to offer legal psychedelic therapy in the U.S.
“DMT is actually the most powerful psychedelic on Earth that we’re aware of, and what makes it special and different from other psychedelics is that it’s endogenous, which means it’s produced within our own bodies. It’s also produced in nearly every ecosystem on Earth — it’s everywhere, it’s all around us – which is also kind of leading to what is really unique about it, the extent of a DMT experience, it’s at most 20 minutes,” Waxenberg said.
While there is a wide range of phenomena experienced during a DMT trip, there are some fascinating common hallmarks.
“This alternate reality experience, or this experience that people will call ‘realer than real.’ It’s a reality similar to our own, but completely different,” Waxenberg said. “Some of the elements within that would be the entity encounters, which is very common for people; intense geometric, hyperbolic shapes; and out-of-body, traveling to the center of the universe; ego-dissolution, ego death; these are really common experiences under it.”
While advocates have been reporting profound healing benefits for decades, there have not been any clinical studies on DMT due to its status as a Schedule 1 controlled substance, until now.
