Ketamine Therapy Proves Powerful For Treatment-Resistant Depression

ketamine therapy

A powerful FDA-approved anesthetic drug once used mainly in operating rooms and on the battlefield is quickly gaining ground as one of the most promising therapies for treatment-resistant mental health conditions.

First discovered as an anesthetic in the 1950s, ketamine has been used in the treatment of a wide range of physical conditions, especially pain management. Starting in the early 1970s, doctors began to find that it can also be very effective in alleviating mental health issues such as depression, anxiety, PTSD, and addiction. Today it is ever more frequently being studied and legally used as an off-label medication to manage conditions that are particularly resistant to treatment with conventional pharmaceuticals.

The latest in a series of recent studies has found that ketamine can quickly and dramatically decrease chronic and suicidal thoughts. Dr. Naveen Thomas is a psychiatrist who has been using ketamine in his practice for years.

“I and many of my colleagues have of course had tremendous success in using ketamine in people who are really suffering from depression. I’ve had a lot of success in treating people with Post-traumatic Stress Disorder,” Dr. Naveen said.

“And some of these folks have spent years and years doing absolutely the best they could using such a wide variety of the conventional treatments, be they various medication treatments, be they various forms of psychotherapy. We’ve seen really wonderful effects.”

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Psychedelic Experiences Neurologically Mimic Near-Death Experiences

Near-death Experience neurally correlates to psychedelic trip

Research suggests the psychedelic trip is remarkably similar to a Near-Death Experience and has been noted for decades. Now, research into the neural activity experienced while under the influence of psychedelics, is providing valuable context for the commonalities.

Dr. Eben Alexander is a neurosurgeon who experienced an NDE in 2008 and has since been studying the phenomenon and sharing his findings in a number of bestselling books.

“This research with psychedelics has been so fascinating,” Alexander said. “Not only does it show that the brain goes dark under the influence of such substances, they actually showed this beautiful inverse correlation between the amount of turning off and dissolution of the Default-Mode Network, as demonstrated on fMRI, with a degree of liberation of consciousness away from the ego into these unfettered realms of transcendental and paranormal experience. It shows us in a very concrete fashion that the brain activity is not actually causing all of this to happen, but it’s more the brain getting out of the way.” 

Researcher Dr. Rick Strassman was the first to rigorously study the overlap between the psychedelic experience and the NDE. The commonalities are quite significant.

“It’s all about entering new realms, I mean, entire immersive experiences — worlds that are different from our material realm. That is a very common theme in those drug experiences as well as in near-death experiences. There’s also this extraordinary world of beings, entities, guides, of intelligences. It’s showing this incredible unification, a sense of being, and a binding force of love through these experiences. So, there’s a commonality of lesson and transformation,” Alexander said.

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